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Protein Engineering and Design Sheldon J. Park, Jennifer R. Cochran
Publisher: CRC Press

Currently there are two methods that have allowed us to make some progress in this problem: directed evolution and rational design. In a sense, the goal of the protein engineer is to find ways to navigate sequence space effectively. Only around 1.5 percent of mammalian DNA encodes proteins. Protein Engineering and Design Publisher: CRC Language: English ISBN: 1420076582 416 pages. Using design and engineering principles learned from nature, a team of biochemists from the University of Pennsylvania School of Medicine have built – from scratch – a completely new type of protein. This is the central problem in protein engineering: how to navigate such an incomprehensibly large space. We often hear from Darwinians that the biological world is replete with examples of shoddy engineering, or, as they prefer to put it, bad design. The design and production of novel peptides and proteins occupy pivotal positions in science and technology and will continue to do so in the 21st century. The key difference in this new project is the opportunity to capitalize on the inherent chemistry and shape of proteins to organize new, designed molecules into desired, arbitrary structures. Somewhere out there may be a protein that can save the world, but it is useless if we can't find it. Creation of the largest human-designed protein boosts protein engineering efforts.